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NAC can inhibit ferroptosis by replenishing intracellular glutathione and supporting GPX4 activity, but its broad mechanism of action makes it difficult to attribute benefits specifically to ferroptosis inhibition ( Key hurdles for clinical translation of ferroptosis inhibitors include ( 5.2 Gut microbial modulators Understanding the role of gut microbiota in ferroptosis opens up exciting possibilities for new therapeutic strategies

DOI: 10.1021/ol070674f

Peripheral inflammatory mediators may also activate the vagus nerve to transmit signals to the central nervous system (Capuron and Miller, 2011)

In the kidney, GLS catalyzes the hydrolysis of glutamine to ammonia and glutamate

Adding the water-soluble glutathione tag marks these compounds for further processing through the mercapturic acid pathway and eventual excretion

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