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Accordingly, one aspect encompassed by the present invention encompasses a diagnostic assay for determining (e.g., detecting) the presence, absence, copy number, amount and/or level of activity of a biomarker described herein (e.g., as listed in table 1 and/or table 2) in the context of a biological sample (e.g., blood, serum, cells or tissue), thereby determining whether an individual having cancer is likely to respond to a cancer therapy (e.g., at least one modulator of a biomarker listed in table 1 and/or table 2), whether in a primary cancer or a recurrent cancer

Preclinical safety at tested doses has been reasonable, but human long-term safety data are not established

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In such conditions, the process of NAD + biosynthesis is frequently impeded or significantly diminished

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