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Description

10.1124/jpet.103.063958 109 LevittE

Boric acid prevents biofilm development and hyphal transformation, both of which protect Candida from antifungals and do not target ergosterol synthesis, so it remains effective against azole-resistant strains

Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM

As there are conflicting opinions on cyclosporin A in the literature, further in vitro and in vivo studies comparing all biological mechanisms involving the peptide would be appropriate

"Executive management should immediately and comprehensively assess your companys global manufacturing operations to ensure that your systems, processes, and products conform to FDA requirements," the agency added