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Estimated prevalence of Barretts in the general population is 5%, and the majority have do not have dysplasia, but if there is high grade dysplasia, there is a 7% annual risk of developing adenocarcinoma, which is what we ultimately want to prevent

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Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7