This blog covers the importance of assessing the 2OH/4OH and 2OH/16OH ratios and provides potential support considerations for suboptimal ratios from a functional medicine perspective
Figure 5 Proof of concept experiments that support the hypothesis of chronic glutamate toxicity in neurodegeneration As EAATs have been found to be down-regulated in many diseases of the nervous system (Sheldon and Robinson, 2007) and hypothetically increased L-glu and L-asp clearance should dampen the excitotoxic component of these diseases, many researchers have set out to identify compounds that induce EAAT2, which is the principal EAAT in the brain and most frequently found to be downregulated (Sheldon and Robinson, 2007
It provides essential protection from free radicals, highly unstable, reactive molecules (also known as reactive oxygen species' (ROS)), which are capable of damaging organic substances such as lipids, proteins and DNA
GA KK01.1.1.01.0007 funded by the European Union through the European Regional Development Fund)
Vaccine 24 , 10281034 (2006)
This historical perspective provides us a list of actions carried out by IGF-I, among others: tissue growth and development, insulin-like activity, proliferative, pro-survival/anti-aging, antioxidant, etc
