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Laugmentation relative de la masse grasse prolonge quant elle laction de certains mdicaments lipophiles, tandis que la baisse des fonctions rnale et hpatique ralentit llimination des mdicaments ainsi que, parfois, de leurs mtabolites actifs ou toxiques, favorisant leur accumulation et augmentant le risque deffets indsirables

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J Neural Transm 127:189203

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