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Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs

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Where the Cardiovascular Concerns Originated Early concerns about TRT and heart disease were driven by studies that had important limitations: Inclusion of frail or acutely ill men Use of high or inconsistent doses Lack of standardized monitoring Short follow-up periods Some studies grouped together men receiving physiologic replacement with those exposed to supraphysiologic levelstwo very different clinical scenarios

Rev 30, 200230 (2021)

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