glutathione conjugation acetaminophen PharmGKB summary: Pathways of metabolism at the therapeutic versus toxic doses The Metabolism of Acetaminophen and

This process is further catalysed by the action of mitochondrial glutamine dehydrogenase (GDH), resulting in the conversion to -ketoglutarate (-KG)

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In this reaction, there is the formation of a peptide bond between an amino acid and drug molecules

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Further studies have found that these two substances mainly exert their corresponding antibacterial effects by targeting the cell membrane of Staphylococcus aureus , causing structural damage to the membrane, and inhibiting the biosynthesis of the cell membrane and cell wall [99]