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1 Introduction Multiple myeloma (MM), a hematologic malignancy characterized by clonal proliferation of bone marrow plasma cells, manifests clinically through CRAB criteria: hypercalcemia, renal dysfunction, anemia, and osteolytic lesions ( Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Zhang et al., 2022

One consequence may be the existence of functional redundancy between isoforms making it difficult to study the biological functions of a particular gene using reverse-genetic approaches

The toxic CP metabolite acrolein promotes excessive ROS production, which damages mitochondrial membranes, induces lipid peroxidation, and impairs DNA integrity

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(17, 18) Glutathione Oral Supplements Here's why you should also look for capsules that focus on bio-availability in order to ensure that the glutathione gets to where it needs to go

doi: 10.1016/S1546-5098(08)60308-8 44 TurnbaughP