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It was found that alcohol promoted an increase in pro-inflammatory bacteria and simultaneously decreased anti-inflammatory bacteria in the gut [163]

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TMAOs effects extend to systemic arterial hypertension and vascular disorders, where elevated levels are associated with unfavorable cardiovascular events

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[123] has calculated that RLS patients who respond to intravenous iron therapy have a decline in weekly ferritin levels of 7.7 3.2 mcg/l/week compared to control normal subjects who decrease by 75 mcg/l [79]