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PMID: 8421672, PMCID: PMC45677, DOI: 10.1073/pnas.90.2.435

Anemia is the predominant cause of morbidity and quality of life impairment in patients with lower-risk (LR)-MDS, and there are very limited therapy options for these patients after failure of erythropoiesis stimulating agents (ESAs)

Accordingly, administration of folic acid in combination with vitamins B 6 and B 12 improved endothelial dysfunction subsequent to hyperhomocysteinemia induced by methionine loading in healthy humans (Chao et al, 1999a)