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Common pathogens include bacteria ( Staphylococcus, Streptococcus, Enterococcus, Pseudomonas aeruginosa, Klebsiella pneumoniae ) and fungi ( Candida, Aspergillus, Mucormycosis, Cryptococcus, Pneumocystis ) ( 3 Intratumoral microbe Emerging evidence suggests that symbiotic bacteria and fungi reside within malignant tumor cells, as revealed by metagenomics and next-generation sequencing ( Fusobacterium dominates colorectal cancer (CRC) niches, while Malassezia enriches in pancreatic tumors (Zepeda-Rivera et al., 2024