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A study conducted at the University of Texas Southwestern Medical Center found that NNMT inhibition in obese mice reduced body weight by 7% over four weeks without changes in food intakea reduction driven entirely by increased energy expenditure

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Nrf2 has antioxidant roles, and increased HO-1 expression reduces oxidative damage and inflammation (125)

Segal JP, Jean-Frdric LeBlanc A, Hart AL

Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A

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