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I do recommend checking out the interesting research compiled by Watanabe & Bito (2017) in the Sources and References list below

[Google Scholar] 64.Wang L., Wu J., Liu Z., Shi Y., Liu J., Xu X., Hao S., Mu P., Deng F., Deng Y

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Other populations may experience effects at lower or higher dosages depending on differences in P-450 enzyme activity and other factors which affect the amount of NAPQI produced

1 2 "Familial idiopathic facial palsy"