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The interactions of aspartame with sweet taste receptors, which have been implicated in the signalling cascade that activates metabolism in the body, and with the gut microbiota were identified by the Working Group as notable research gaps

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(R)-N-(2-Chlor-6-methylphenyl)-2-[[[(2-hydroxy-1-phenylethyl)amino]carbonyl]amino]-6-benzothiazolcarboxamid

Therapies targeting mismatch repair, such as small-molecule MSH3 inhibitors or ASOs, represent a promising avenue for combating HD at its genetic roots (Moss et al