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As observed for B6, contraction of the dihydropyrrole and diazepine ring from m/z 359.9968 can yield m/z 314.9757 (C 14 H 8 BrN 2 O 2 + , 2.2 ppm)

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Glutathione synthesis is ATP-consuming and depends on the availability of the amino acids cysteine, glutamine and glycine and requires two subsequent reactions, in which -glutamylcysteine synthetase (-ECS or GSH1, EC 6.3.2.2) first catalyzes the formation of -glutamylcysteine (-EC) from cysteine and glutamine and glutathione synthetase (GSHS or GSHS2, EC 6.3.2.3), then catalyzes the formation of glutathione from -EC and glycine

The GPR30 receptor agonist G1 inhibits ferroptosis and significantly improves chondrocyte viability and motor ability in mice through the YAP1/FTH1 pathway, while GPR30 receptor antagonist G15 has the opposite effect, suggesting that hormone-related ferroptosis may emerge as a promising target for alleviating osteoarthritis in postmenopausal women

The glutamine transporter asct2 (slc1a5) promotes tumor growth independently of the amino acid transporter lat1 (slc7a5)