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Intestinal epithelial cells express both HIF1 and HIF2 with non-redundant roles [115], and both are overexpressed in several tumors, including CRC [116, 117]

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In vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy

When Maris pitched Googles founders, Sergey Brin, who has a gene variant that predisposes him to Parkinsons disease, loved the idea, and Larry Page declared, We should do it here! In 2013, Google launched Calico, short for the California Life Company, with a billion dollars in funding

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