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Clinical studies found that semaglutide was effective on its ownwithout B12finding that people lost an average of 15% of body weight over 68 weeks

Diabetic retinopathy complications have been observed in some patients with pre-existing retinopathy who experience rapid improvements in glycemic control with semaglutide therapy

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However, if your B12 levels are already within a healthy range, you may not experience a dramatic or long-lasting energy boost

There is not much direct clinical evidence that B12 supplementation can reduce systemic histamine levels or end HIT

Others who might be prescribed B12 shots are those at the highest risk for a B12 deficiency, including: Vegans, since vitamin B12 is found only in animal products People ages 60 and up since their bodies don't absorb B12 as efficiently People with Crohn's disease or pancreatic disease, since they prevent nutrient absorption People who had weight-loss surgery, which decreases B12 absorption People with an eating disorder People with HIV People with diabetes Since a mild B12 deficiency might not cause symptoms, it can go undetected for years since levels are not checked during routine blood work