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5.2 Dose effect and safety issues 5.2.1 Dose-dependent safety concerns for functional food active ingredients Emerging evidence reveals significant population-specific toxicity risks for several widely consumed functional food ingredients, with genetic factors, smoking status, and concurrent medications dramatically altering safety profiles (239)

[Abstract]2024 Jan 6;51(1):86

demonstrated that intramuscular vitamin E injection could lower MDA expression and lipid peroxidation and enhance plasmas antioxidant capacity

Subsequently, Fe 2+ exported by ferroportin (FPN-1) can be oxidized to Fe 3+ by membrane-bound ceruloplasmin, which in turn binds to transferrin (TF) to form TF-Fe 3+ , which is referred to as holotransferrin (transferrin bound to two iron atoms

doi: 10.1213/00000539-198412000-00005 31 FassoulakiA.KaniarisP.VaronosD

Subsequently, the dried residues were derivatized with methoxylamine hydrochloride and N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (TBDMS) sequentially