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Epidemiological data indicate that approximately 7 million people worldwide are affected by PD, a figure projected to rise to 12 million by 2040 (Tichelaar et al., 2023)

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This can be measured every 1-2 weeks and is sensitive to recent changes in medication

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Glutathione - Synthesis SFRBM Education Program Dickinson et al.9 de novo synthesis - 3 The GCL holoenzyme is a heterodimer of ~104 kDa

Dysregulated mTOR signaling and defective chaperone-mediated autophagy further inhibit proteostasis (Behl et al., 2022