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Chen YX, Li S, Wang R, Miao J, Zhong

Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA

QMP substitutions compensate for decreased FcRn binding caused by L585 cleavage The three amino acid substitutions introduced in DIII of human albumin, QMP, greatly improve its pH-dependent binding to human FcRn (Fig

The gene product, ALDH2, localises to the mitochondria where it catalyses the detoxification of aldehydes

These findings are derived from controlled research environments and are intended solely to advance scientific understanding of cellular aging mechanisms and peptideDNA interactions