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Furthermore, this review is not intended and should not be interpreted to make recommendations or claims regarding the legality of compounding any specific preparation using any substance covered in this review

Reed MK, Salcedo VJ, Hsiao T, Esteves Camacho T, Salvatore A, Siegler A, et al

Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism

CNS Neurosci Ther 31:e70511

Primary hypothermia results from exposure to a cold environment that overcomes the bodys capacity for heat production via mechanisms such as exercise or shivering

However, the review rated the overall evidence quality as very low due to small sample sizes, short follow-up periods, high risk of bias, and predominantly manufacturer-funded studies