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J.Catal-MoraJ.Zann-MorenoV.LopezM.et al

The progressive hypoxia of liver microenvironment during HBV infection directly or indirectly changes the activity, proliferation and cytokine secretion of CD8 + T cells, and is accompanied by corresponding metabolic reprogramming, which is manifested as increased cellular glycolysis, glutamine metabolism and FAS, decreased OXPHOS, mitochondrial dysfunction and abnormal amino acid metabolism