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Recent clinical studies using 1 H-MRS showed that GSH levels in the brains of ALS patients were decreased compared to those of age-matched healthy volunteers [111], and the decreased GSH levels in the motor cortex and corticospinal tract were inversely correlated with the time after diagnosis [112]

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In 8-12 weeks , the above changes become more apparent

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A potential treatment strategy for TMJ OA could be the injection of the ferroptosis inhibitor Lip-1, which successfully reduced chondrocyte ferroptosis, restored mitochondrial function, decreased ROS and lipid peroxidation, and improved the integrity of the cartilage matrix [100]