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Curr Opin Toxicol 19:3441

In the tumor microenvironment, macrophages frequently exhibiting DNA damage promote immune escape by secreting immunosuppressive factors such as IL-10 and TGF-, whereas during aging, persistent DNA damage in macrophages alters their secretory phenotype, fostering chronic inflammatory conditions in tissues (Fig

[DOI] [PubMed] [Google Scholar] 119.Allameh A, Niayesh-Mehr R, Aliarab A, Sebastiani G, Pantopoulos K

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Ethics declarations Ethics approval and consent to participate All animal experiments were complied with the ARRIVE guidelines and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals