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For this reason, MTHFR hypermethylation gene promoter appears to emerge as a new putative risk factor in the spontaneous abortion aetiology (Reference Rotondo, Bosi and Bazzan22)

16 The protocol was registered with PROSPERO 17,18 (CRD420250391405)

Cranial MRI may reveal cerebral atrophy, loss of white matter around the ventricles, cortical thickening, nodular ectopic, thinning of the corpus callosum, and ventricular dilatation [29]