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To examine whether the chemical conjugation of MK-801 to GLP-1 mitigates the adverse hyperthermic and hyperlocomotive effects of MK-801, mice were subjected to body temperature measurements and open-field behavioural tests after chronic and acute drug administration, respectively

Despite multimodal treatments, recurrence is almost inevitable, partially due to the difficulty of complete surgical removal, with a median interval of less than 10 months 6,7,8

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Serious adverse effects are uncommon but possible, including allergic reactions, severe injection site reactions if improper technique is used, and excessive detoxification responses in susceptible individuals

Tesofensine is a CNS-active triple monoamine reuptake inhibitor that suppresses appetite by prolonging serotonin, norepinephrine, and dopamine signaling in the brain