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Further studies have shown that due to heme-induced mitochondrial oxidative stress, the present ALAS2 transgenic mice has exhibited an increase in heme accumulation, aggravation of cell death, and exacerbation of cardiac dysfunction after coronary ligation compared with the control littermates (Sawicki et al., 2015b)

Thus, intravenous N-acetylcysteine (NAC) is the antidote for APAP overdose given in Emergency Departments

The most extensively studied areas include the accelerated healing of musculoskeletal tissues like tendons, ligaments, and muscles, as well as its protective and reparative effects on the gastrointestinal tract

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Their correlation analysis also showed that the gut barrier and lipopolysaccharide (LPS) content in the serum were strongly associated with behavioral performance and the biochemical indexes of the brain

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