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Parkinsons disease PD is characterized by degeneration of dopaminergic neurons, affecting millions of people worldwide and ranking as the second most common condition of its kind after Alzheimers disease 32

A substantial amount of evidence has shown dysregulation of FGFR signaling as a pathogenic mechanism and consequence of cancer, 93 and it is frequently detected to be highly expressed in HCC, contributing to tumorigenesis, progression, and drug resistance

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Although some of these mechanisms were initially identified in tumor or fibrosis models [102], their relevance to PH is profound: the resulting accumulation of M2 macrophages leads to the secretion of pro-fibrotic and pro-proliferative factors

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