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Actinidia arguta extract attenuates inflammasome activation: potential involvement in NLRP3 ubiquitination

doi: 10.1016/j.freeradbiomed.2020.12.002 42 CouplandK

In addition, thymosin alpha-1 has been studied in sepsis-related research due to its ability to modulate immune responses and potentially improve outcomes in severe infection-driven inflammatory states

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At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity