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The frequency, duration and intensity of muscle cramps were reduced by taurine treatment (2 g per day, p.o) in a recent clinical study on patients with chronic liver disease [167]

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Thus, TNBS promotes two independent mechanisms of injury, GSH depletion and ROS generation, both being required for the manifestation of mucosal injury as GSH limitation renders intestine susceptible to the TNBS-induced ROS overgeneration