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Abbreviations AICD: Amyloid precursor protein intracellular domain APP: Amyloid precursor protein BDNF: Brain-derived neurotrophic factor CHOP: CCAAT enhancer-binding protein homologous protein C/N: Carbon to nitrogen ERK: Extracellular-signal-regulated kinase IDE: Insulin-degrading enzyme iNOS: Inducible NO synthase IRE1 : Inositol-requiring enzyme 1 JNK: c-Jun N-terminal protein kinase MAPK: Mitogen-activated protein kinase MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPP + : 1-Methyl-4-phenylpyridinium NeuN: Neuronal nuclei NF- B: Nuclear factor kappa light chain enhancer of activated B cells NGF: Nerve growth factor PD: Parkinson's disease proNGF: NGF precursor RNS: Reactive nitrogen species TRAF2: Tumor necrosis factor receptor-associated factor 2 v / v : Volume/volume