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Inadequate B12 levels impair: High-Risk Groups for Vitamin B12 Deficiency Vegetarians and Vegans Plant-based diets naturally contain minimal vitamin B12, as this nutrient occurs primarily in animal products

Pernicious anaemia is a megaloblastic anaemia, because a lack of vitamin B12 also commonly referred to as cobalamin can cause abnormality in haematopoietic cell maturation[2]

Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

Koch & Reimer, 2012)

R., Maheshwari, A., Nusrat, A

Ischemia-induced oxidative stress and inflammation worsen epithelial damage, which leads in an increased permeability of the intestinal lining, allowing the transfer of bacteria, their products, and toxins from the gut lumen into the circulation (Liao et al., 2022)