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USA 106 , 35973602 (2009)

Dominici EM, Lopez ER, Vang MT, Tamayo AT, Ou Z, Rollo A, Zhang L, Wang J, Strickland LM, Wang M , Ford RJ, Pham LV, Kirk CJ

In 3xTg-AD mice, dietary SAMe supplementation reduced hippocampal A and phosphorylated tau, and delayed the accumulation of extracellular A, demonstrating SAMes ability to modulate the time course of AD neuropathology (21, 23)

The Energy and Cognitive Complex B-vitamins specifically B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), and B6 (pyridoxine) are essential cofactors in cellular energy production

11. Cabreiro F et al

A nutritious diet supports production, but supplementation helps bridge the gap during periods of stress or high environmental exposure.