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Evidence showed that fatty acid synthesis is markedly upregulated during differentiation of primary human monocytes, and its inhibition reduces macrophage phagocytosis, which can be fully rescued by supplementation with a fatty acid-CoA mixture (34)

All animal experiments were performed in accordance with the guidelines of the Ethics Committee of the Fifth Affiliated Hospital of Zhengzhou University (KY2023038)

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Additionally, other studies have indicated that madecassoside can significantly inhibit the migration ability of KFs by suppressing the activity of the p38 mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways, reducing the phosphorylation level of cofilin, and decreasing the formation of F-actin filaments

97 IDA's complex pathogenesis might be driven by a lowered erythropoietin response, decreased RBC survival along with reduced iron absorption and macrophageal iron retention, limiting iron delivery to erythroid precursor cells