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In addition to the epithelial cells, endothelial cells (ECs) are also effector cells during CS-induced emphysema, as the volatile components in CS, such as aldehyde and acrolein, can directly enter into the blood vessels, causing EC injury (Kim et al., 2016

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In fact, FMO1 is also participated in the oxidization of TMA to TMAO, however, its specific activity is only 1/10 that of FMO3 (Bennett et al., 2013)