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Interfaces , 16 , 2353623552 (2025)

The pathogenesis of RA has been correlated to imbalances in the content of oral and intestinal microorganisms

The influence of bacteria and irritation in the initiation of periodontal disease in germfree and conventional rats

The liver relies heavily on glutathione during its detoxification processes

This bidirectionality may explain why some nutrient interventions fail [e.g., vitamin B12 supplementation is ineffective in patients with gut microbiota dysbiosis (149)]

An integrative strategy should also incorporate in vivo selectivity assays, transcriptomic co-expression analyses, and disease-contextualized transporter profiling to ensure beneficial neuromodulatory effects while minimizing compensatory or deleterious responses