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Initiation of autoimmunity: loss of self-tolerance Autoimmune destruction of beta cells is initiated by loss of immune tolerance, mainly through two interconnected pathways

According to the effects discussed above, DCA seems the only drug that targets simultaneously most of the proteins and pathways involved in CC pathogenesis

W., Lund, A

Ferroptosis is an iron-dependent non-apoptotic type of cell death caused by intracellular lipid peroxidation metabolism disorder, which is mainly characterized by the accumulation of lipid peroxides and the overload of iron ions (6)

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