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Norethisterone is generally well tolerated but the following side effects tend to be the most common: Bleeding disorders eg Breakthrough bleeding, spotting, amenorrhea Breast tenderness Headache Dizziness, Fatigue Nausea, Vomiting Acne Fluid retention, bloating If you notice any of the symptoms below, discontinue Norethisterone immediately and speak to your doctor or pharmacist

This is important because transfusion interval is not just a theoretical marker but a direct measure of disease burden and hospital dependency in daily life

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Store reconstituted vials refrigerated at 2 to 8 degrees Celsius

Consider safety syringes if needlestick injury is a concern

Those most likely to benefit include: Individuals with diagnosed or suspected vitamin B12 deficiency