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Results Overall and sex-specific associations of genetically predicted l-carnitine with CVD Genetically predicted higher l-carnitine was nominally associated with higher risk of CAD and heart failure in men and women, with odds ratio (OR) 1.07 (95% confidence interval (CI) 1.02 to 1.11) for CAD and OR 1.05 (95% CI 1.01 to 1.09) for heart failure per standard deviation (SD) increase in genetically predicted l-carnitine (Fig

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Novel techniques, such as single-cell sequencing, could be applied to further clarify the metabolic shift in each cell types and patterns of cellcell cross talk in different cancers

In brains of sporadic PD patients with diffuse Lewy bodies, s-nitrosylation of Parkin 120 , p53 120 , PTEN, and DJ-1 121 have been reported that result from an interlinked mechanism of trans-nitrosylation leading to degeneration of nigral neurons