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they are deeply interconnected, often tracing back to a central hub of health: the gut microbiome and the intestinal barrier

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The FXR agonist did not reduce intestinal bacterial overgrowth in mice lacking FXR, which means that the antimicrobial action of the FXR agonist was due to the FXR mediating the activation of bile acid synthesis and not to the biochemical properties of the administered FXR agonist

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NETosis is induced dependent on ROS, which majorly originates from nicotinamide adenine dinucleotide phosphate oxidases, whose activation is dependent on an elevation in cytoplasmic Ca 2+ concentration and occasionally on ROS generation in the mitochondria (144)

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