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A randomized, double-blind, controlled phase II trial in advanced renal cell carcinoma (RCC) demonstrated synergistic anticancer effects with the combination of the glutaminase inhibitor telaglenastat (CB-839) and the mTOR inhibitor everolimus (TelaE), which was well tolerated by patients previously treated with TKIs

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This eventually prevents mitochondrial damage and the cytosolic release of oxidized mtDNA, a direct activator of NLRP3, limiting the processing of mature IL-1 69

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Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients