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In particular, cation 2k may be prepared from quinoline-N-oxide 14 or the like, which may be derived from quinoline via a mCPBA oxidation (Scheme 4)

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In some cases of long-term severe deficiency, healing of the nerve damage may be extremely slow, requiring maintenance of B12 levels for months to achieve optimal recovery

Fusion primers with dual-indexed PCR adapters were used to generate the construct library, and short fragments were removed with AMPure beads