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Cell Signal 99:110450 Kale J, Osterlund EJ, Andrews DW (2018) BCL-2 family proteins: changing partners in the dance towards death

The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001

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Quality control sample was injected every six samples

Indeed, faecal miR-135b exhibits high sensitivity and specificity for distinguishing patients with CRC from healthy controls, with sensitivity rates up to 96.5% and specificity rates up to 87.2% suggesting potential as a screening test for CRC (186,187)