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In principle, as emphasized before (11), external fistulas form an anomalous connection between skin and gastrointestinal tract that provides a direct and unusual contact between these different, normally separated, tissues, thereby resulting in special new circumstances and healing difficulties, and a failure of regular healing that is otherwise not present

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In particular, throughout this maturation phase, there is a notable upregulation of miR-486, miR-10b, miR-10a-5p, miR-183, and miR-21, whereas there is a notable downregulation of miR-210 and miR-27b-3p expression

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This non-invasive approach to urine cytokine analysis also provides important information regarding the pathological bladder conditions in patients with IC/BPS and OAB