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Proc Natl Acad Sci U S A (2009) 106(2):5705

The glutathione redutase recycles GSSG to GSH with simultaneous oxidation of b-nicotinamide adenine dinuclecotide phosphate

Activated T cells undergo proliferation and differentiate into memory T cells and effector T cells

The photoluminescence (PL) spectra were measured by a Fluorolog-3 in TCSPC mode (HORIBA Scientific)

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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51