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Figure 2 Oxidative insult and male hormones in reproduction The occurrence of oxidative stress depends on either the overproduction of ROS or depletion of antioxidants, which may result in lipid peroxidation in Leydig cells and germ cells and is detrimental to lipoproteins, protein aggregation and fragmentation, and steroidogenic enzyme inhibition (43)

Mol Cell (2019) 75:114760.e5

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