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These nanoplatforms have demonstrated the ability not only to eradicate primary tumors but also to suppress metastatic lesions through systemic immune activation [294, 295]

The decrease of NAD + levels related to aging might weaken SASP and reduce its pathological effect

doi: 10.1080/09273948.2018.1560477 73 HuJWangCHuangXYiSPanSZhangYet al

For treatment of metastatic cancers, moreover, chemotherapeutics with combinational regimens is often considered the first-line treatment option in clinical settings

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