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It is also noteworthy that the k cat of the two enzymes also differ by 3-fold, something that we cannot explain using static structures and may involve distinctions in active site motion, as outlined elegantly for other enzyme systems 30

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Peripheral smears characteristically show small, mature-appearing lymphocytes and fragile smudge cells

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Ap- proaching more comprehensive hormonal evaluation considering not only seric levels, but the products of hepatic metabolism will provide more data so that we can build more personalized thera- peutic interventions in womens common disorders as endome- triosis, menopause, lipedema and estrogen-related cancer