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How neurons die in Alzheimer's disease: Implications for neuroinflammation

However, these findings are challenged by a recent study that the loss of UCHL5 activity also impairs global protein turnover ( Accumulating evidence suggests a protumor role of proteasomal DUBs in different cancers

10.1016/j.celrep.2017.05.007 Cell Rep

Shank3B knockout (Shank3B /) mice exhibit hypersensitivity to tactile stimuli, which correlates closely with increased spontaneous discharge and stimulus-evoked activity in pyramidal neurons, as well as reduced activity in interneurons, within the primary somatosensory cortex (vS1)

Interestingly, a distinct cluster was marked by the IGFBP5 gene (Fig

Nahar K, Hasanuzzaman M, Alam MM, Fujita M (2015) Exogenous glutathione confers high temperature stress tolerance in mung bean (Vigna radiata L.) by modulating antioxidant defense and methylglyoxal detoxification system